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  • CVD Risk from Ketogenic Diets

    A recent analysis of the UK Biobank data found that subjects on a low-carbohydrate, high-fat diet had higher levels of low-density lipoprotein cholesterol and apolipoprotein B, and an increase in incident major adverse cardiovascular events over a 12-year follow-up than subjects on a standard diet.

  • Risk of Atherosclerotic Coronary Artery Disease in Autoimmune Disorders

    A large Danish registry study of patients with autoimmune disease referred for coronary computed tomography angiography compared to those without autoimmune disease has shown that autoimmune disease increases the incidence of atherosclerotic events and that the event rate is influenced by traditional atherosclerotic disease risk factors. These results support aggressive risk factor management in patients with autoimmune disease.

  • The Role of Pulmonary Hypertension in the Decision to Intervene in Degenerative Mitral Regurgitation

    A retrospective observational study of patients with degenerative mitral valve regurgitation has shown that Doppler echocardiographic-determined elevated pulmonary artery systolic pressure is related to mortality independent of the severity of mitral regurgitation, and that this excess mortality can be attenuated by mitral valve surgery.

  • Hypothermia and Frostbite

    Hypothermia is a medical emergency that requires immediate attention and correction. For patients with environmental exposures, especially freezing ambient temperatures, cold water, snow, and ice, frostbite injuries are of significant concern.

  • How Do the Rhythm and 12-Lead Go Together?

    The patient whose electrocardiogram (ECG) is shown presented for care because of chest pain. Looking at this ECG, can you determine why?

  • Imetelstat Injection (Rytelo)

    The U.S. Food and Drug Administration has approved a first-in-class telomerase inhibitor for the treatment of myelodysplastic syndrome with transfusion-dependent anemia.

  • Being Mindful of COVID’s Effects on Cognitive Decline

    A large observational study finds objective evidence of lingering cognitive deficits associated with past COVID-19 infection, particularly in patients infected early in the pandemic, those hospitalized, or those with prolonged illness duration.

  • Summer Travel: News Clinicians (and Their Patients) Can Use

    The pandemic has waned. Summer vacation has arrived. Airports are crowded. Planes are full. New science can guide us as we and our patients travel this season.

  • A Review of HIV Pre-Exposure Prophylaxis

    Knowing one’s human immunodeficiency virus (HIV) status can help patients take steps to prevent transmission. Male and female condoms are options for preventing HIV during sexual intercourse. These products are widely available over the counter in retail stores and pharmacies and their use should be encouraged for preventing sexually transmitted infections. Yet, there is another option available, pre-exposure prophylaxis (PrEP), for patients to prevent HIV that many providers have not yet added to their armamentarium. This special feature will review the indications for PrEP, its use, and the medications recommended.

  • Comparing Medications Used for Lactation Inhibition

    A randomized controlled trial demonstrated superior efficacy of cabergoline compared to pyridoxine (78% vs. 35%; P < 0.001) at suppression of lactation seven days after delivery.